A new study establishes a direct causal link between IgLON5 antibodies and Tau pathology. By applying patient antibodies to mouse models, the team discovered that antibody-induced clustering of cell-surface IgLON5 proteins sparks profound neuronal hyperactivity.
A new study establishes a direct causal link between IgLON5 antibodies and Tau pathology. By applying patient antibodies to mouse models, the team discovered that antibody-induced clustering of cell-surface IgLON5 proteins sparks profound neuronal hyperactivity.
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